Presumably used on human slaves or enemies the Harkonnens. In the film, Harkonnens typically install heart plugs on their slaves in order to control them. In the book they use poisons, if I recall correctly.
One of these is the heart – plugs. Not present in the original novel, these medical intrusions act as an instant-death pull-switch for the Harkonnen .
The Heart Plug is an item that can be found in the Cave entrance. The prevention of strokes has traditionally been plagued by the tedious task of continuously adjusting anti-coagulation medicines. Cut from the game, this scene sees the Baron plugging the plug on your predecessor.
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